Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …

Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the surrounding
microenvironment in both normal physiology and pathological conditions. While MSCs …

Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy
characterized by excessive proliferation and accumulation of immature myeloid blasts in the …

Parkinson's disease (PD) is a chronic and complex disease of the central nervous system
(CNS). Progressive loss of dopamine (DA) neurons in midbrain substantia nigra is …

Polysaccharides are macromolecules obtained from a wide range of sources and are known
to have diverse biological activities. The biological activities of polysaccharides depend on …

Background Glyphosate is the most widely applied herbicide worldwide, and its use has
been associated with increased risks of certain hematopoietic cancers in epidemiologic …

Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases leading to an insufficient formation of functional blood …

Myeloid leukemic cells are intrinsically under oxidative stress due to impaired reactive
oxygen species (ROS) homeostasis, a common signature of several hematological …

Fms-like tyrosine kinase 3 (FLT3) is an important member of the class III receptor tyrosine
kinase (RTK) family, which is involved in the proliferation of hematopoietic cells and …