Mechanisms of cellular invasion by intracellular parasites

DM Walker, S Oghumu, G Gupta, BS McGwire… - Cellular and molecular …, 2014 - Springer
Numerous disease-causing parasites must invade host cells in order to prosper.
Collectively, such pathogens are responsible for a staggering amount of human sickness …

[HTML][HTML] Vaccines against Toxoplasma gondii: challenges and opportunities

E Jongert, CW Roberts, N Gargano… - Memórias do instituto …, 2009 - SciELO Brasil
Development of vaccines against Toxoplasma gondii infection in humans is of high priority,
given the high burden of disease in some areas of the world like South America, and the …

Current status of toxoplasmosis vaccine development

J Kur, L Holec-Gąsior… - Expert review of …, 2009 - Taylor & Francis
Toxoplasmosis, caused by an intracellular protozoan parasite, Toxoplasma gondii, is
widespread throughout the world. The disease is of major medical and veterinary …

A systematic review of Toxoplasma gondii antigens to find the best vaccine candidates for immunization

F Rezaei, S Sarvi, M Sharif, SH Hejazi… - Microbial …, 2019 - Elsevier
At present, there is not any available accepted vaccine for prevention of Toxoplasma gondii
(T. gondii) in human and animals. We conducted literature search through English (Google …

Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential

G Dautu, B Munyaka, G Carmen, G Zhang… - Experimental …, 2007 - Elsevier
A combination of antigenic regions of microneme proteins have been previously reported as
being protective against chronic toxoplasmosis. In this work, we evaluated immune …

Atomic resolution insight into host cell recognition by Toxoplasma gondii

TMA Blumenschein, N Friedrich, RA Childs… - The EMBO …, 2007 - embopress.org
The obligate intracellular parasite Toxoplasma gondii, a member of the phylum Apicomplexa
that includes Plasmodium spp., is one of the most widespread parasites and the causative …

Vaccination with recombinant microneme proteins confers protection against experimental toxoplasmosis in mice

CF Pinzan, A Sardinha-Silva, F Almeida, L Lai… - PloS one, 2015 - journals.plos.org
Toxoplasmosis, a zoonotic disease caused by Toxoplasma gondii, is an important public
health problem and veterinary concern. Although there is no vaccine for human …

Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans

TG Tan, E Mui, H Cong, WH Witola, A Montpetit… - Vaccine, 2010 - Elsevier
Toxoplasma gondii is an intracellular parasite that causes severe neurologic and ocular
disease in immune-compromised and congenitally infected individuals. There is no vaccine …

Protective Immunity Induced by Toxoplasma gondii Rhoptry Protein 16 against Toxoplasmosis in Mice

ZG Yuan, XX Zhang, XH He, E Petersen… - Clinical and Vaccine …, 2011 - Am Soc Microbiol
Toxoplasma gondii can infect a large variety of domestic and wild animals and human
beings, sometimes causing severe pathology. Rhoptries are involved in T. gondii invasion …

Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid A (MPL) adjuvant against Toxoplasma …

M Golkar, MA Shokrgozar, S Rafati, K Musset… - Vaccine, 2007 - Elsevier
To investigate the vaccine potential of both the Toxoplasma GRA2 and GRA6 antigens, the
full length recombinant proteins were produced in Escherichia coli, formulated in MPL …