CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …

Single-cell and single-nucleus genomic approaches can provide unbiased and multimodal
insights. Here, we discuss what constitutes a molecular cell atlas and how to leverage single …

As the field of single-cell transcriptomics matures, research is shifting focus from
phenomenological descriptions of cellular phenotypes to a mechanistic understanding of the …

Aging is characterized by a decline in tissue function, but the underlying changes at cellular
resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a …

T cells develop from circulating precursor cells, which enter the thymus and migrate through
specialized subcompartments that support their maturation and selection. In humans, this …

Human embryonic bone and joint formation is determined by coordinated differentiation of
progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory …

The human vascular system, comprising endothelial (EC) and mural cells, covers a vast
surface area in the body, providing a critical interface between blood and tissue …

The rapid growth of single-cell transcriptomic technology has produced an increasing
number of datasets for both embryonic development and in vitro pluripotent stem cell …

Microglia shift toward an inflammatory phenotype during aging that is thought to exacerbate
age-related neurodegeneration. The molecular and cellular signals that resolve …

Idiopathic pulmonary fibrosis (IPF) is a chronic parenchymal lung disease characterized by
repetitive alveolar cell injury, myofibroblast proliferation, and excessive extracellular matrix …