cAMP signaling in ovarian physiology in teleosts: A review

T Takahashi, K Ogiwara - Cellular Signalling, 2023 - Elsevier
Ovarian function in teleosts, like in other vertebrates, is regulated by two distinct
gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) …

Allosteric modulation of gonadotropin receptors

C Lazzaretti, M Simoni, L Casarini… - Frontiers in …, 2023 - frontiersin.org
Gonadotropins regulate reproductive functions by binding to G protein-coupled receptors
(FSHR and LHCGR) expressed in the gonads. They activate multiple, cell-specific signalling …

Expression and function of the luteinizing hormone choriogonadotropin receptor in human endometrial stromal cells

ON Mann, CS Kong, ES Lucas, JJ Brosens… - Scientific reports, 2022 - nature.com
The human luteinising hormone choriogonadotropin receptor (LHCGR) is a G-protein
coupled receptor activated by both human chorionic gonadotropin (hCG) and luteinizing …

ATP10A deficiency results in male-specific infertility in mice

AC Norris, EM Yazlovitskaya, TS Yang… - Frontiers in Cell and …, 2024 - frontiersin.org
Over 8% of couples worldwide are affected by infertility and nearly half of these cases are
due to male-specific issues where the underlying cause is often unknown. Therefore …

Effects and action mechanism of gonadotropins on ovarian follicular cells: A novel role of Sphingosine-1-Phosphate (S1P). A review

A Guzmán, AM Rosales-Torres… - General and …, 2024 - Elsevier
Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) control antral follicular
growth by regulating several processes, such as the synthesis of hormones and signaling …

FSH dose is negatively correlated with number of oocytes retrieved: analysis of a data set with~ 650,000 ART cycles that previously identified an inverse relationship …

ZL Clark, M Thakur, RE Leach, JJ Ireland - Journal of Assisted …, 2021 - Springer
Purpose To evaluate whether total FSH dose was negatively correlated with number of
oocytes retrieved in a large data set where previously, a negative correlation between FSH …

[HTML][HTML] Characterization of gonadotropins and their receptors in a chondrichthyan, Scyliorhinus canicula, fills a gap in the understanding of their coevolution

F Jeanne, S Pilet, D Klett, Y Combarnous… - General and …, 2024 - Elsevier
In Gnathostomes, reproduction is mainly controlled by the hypothalamic-pituitary–gonadal
(HPG) axis, with the involvement of the pituitary gonadotropic hormones (GTH), follicle …

Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: enhanced transcription and PI3K and MAPK signaling

G Hua, JW George, KL Clark, KC Jonas… - Human …, 2021 - academic.oup.com
STUDY QUESTION Does hypo-glycosylated human recombinant FSH (hFSH18/21) have
greater in vivo bioactivity that drives follicle development in vivo compared to fully …

Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase

JR Egbert, I Silbern, TF Uliasz, KM Lowther… - Biology of …, 2024 - academic.oup.com
In response to luteinizing hormone (LH), multiple proteins in rat and mouse granulosa cells
are rapidly dephosphorylated, but the responsible phosphatases remain to be identified …

Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism

J Duan, XH He, SJ Li, HE Xu - Nature Reviews Endocrinology, 2024 - nature.com
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors, with
many GPCRs having crucial roles in endocrinology and metabolism. Cryogenic electron …