Targeting plasmids to limit acquisition and transmission of antimicrobial resistance
Antimicrobial resistance (AMR) is a significant global threat to both public health and the
environment. The emergence and expansion of AMR is sustained by the enormous diversity …
environment. The emergence and expansion of AMR is sustained by the enormous diversity …
Multidrug resistance (MDR) and collateral sensitivity in bacteria, with special attention to genetic and evolutionary aspects and to the perspectives of antimicrobial …
Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …
Emergence of colistin-resistant hypervirulent Klebsiella pneumoniae (CoR-HvKp) in China
X Liu, Y Wu, Y Zhu, P Jia, X Li, X Jia, W Yu… - Emerging Microbes & …, 2022 - Taylor & Francis
Colistin is regarded as a last-resort agent to combat infections caused by multidrug-resistant
(MDR) Gram-negative bacteria, especially carbapenem-resistant isolates. In recent years …
(MDR) Gram-negative bacteria, especially carbapenem-resistant isolates. In recent years …
In vitro activity of ceftazidime/avibactam against isolates of carbapenem-non-susceptible Enterobacteriaceae collected during the INFORM global surveillance …
I Spiliopoulou, K Kazmierczak… - Journal of Antimicrobial …, 2020 - academic.oup.com
Objectives To report data for ceftazidime/avibactam and comparators against meropenem-
non-susceptible Enterobacteriaceae collected globally (excluding centres in the USA) from …
non-susceptible Enterobacteriaceae collected globally (excluding centres in the USA) from …
Molecular Epidemiological Insights into Colistin-Resistant and Carbapenemases-Producing Clinical Klebsiella pneumoniae Isolates
D Di Tella, M Tamburro, G Guerrizio… - Infection and Drug …, 2019 - Taylor & Francis
Purpose Carbapenemases-producing Klebsiella pneumoniae are challenging antimicrobial
therapy of hospitalised patients, which is further complicated by colistin resistance. This …
therapy of hospitalised patients, which is further complicated by colistin resistance. This …
Prevalence of Mutated Colistin-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis
NY Yusof, NII Norazzman, SNWA Hakim… - Tropical Medicine and …, 2022 - mdpi.com
The emergence of genetic mutations in chromosomal genes and the transmissible plasmid-
mediated colistin resistance gene may have helped in the spread of colistin resistance …
mediated colistin resistance gene may have helped in the spread of colistin resistance …
Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020
M Falcone, C Giordano, S Barnini, G Tiseo… - …, 2020 - eurosurveillance.org
A large outbreak of New Delhi metallo-beta-lactamase (NDM)-1-producing Klebsiella
pneumoniae sequence type (ST) 147 occurred in Tuscany, Italy in 2018–2019. In 2020 …
pneumoniae sequence type (ST) 147 occurred in Tuscany, Italy in 2018–2019. In 2020 …
[HTML][HTML] Metagenomics analysis of probable transmission of determinants of antibiotic resistance from wastewater to the environment–A case study
W Zieliński, J Hubeny, M Buta-Hubeny… - Science of the Total …, 2022 - Elsevier
During mechanical-biological treatment, wastewater droplets reach the air with bioaerosols
and pose a health threat to wastewater treatment plant (WWTP) employees and nearby …
and pose a health threat to wastewater treatment plant (WWTP) employees and nearby …
Emergence of Polymyxin Resistance in Clinical Klebsiella pneumoniae Through Diverse Genetic Adaptations: A Genomic, Retrospective Cohort Study
N Macesic, B Nelson, TH Mcconville… - Clinical Infectious …, 2020 - academic.oup.com
Background Polymyxins are antimicrobials of last resort for the treatment of carbapenem-
resistant Enterobacteriaceae, but resistance in 5% to> 40% isolates has been reported. We …
resistant Enterobacteriaceae, but resistance in 5% to> 40% isolates has been reported. We …
Prevalence of insertion sequence elements in plasmids relating to mgrB gene disruption causing colistin resistance in Klebsiella pneumoniae
SME Fordham, A Mantzouratou… - Microbiologyopen, 2022 - Wiley Online Library
Colistin is a last resort antibiotic for the treatment of carbapenemase producing Klebsiella
pneumoniae. The disruption of the mgrB gene by insertion sequences (ISs) is a mechanism …
pneumoniae. The disruption of the mgrB gene by insertion sequences (ISs) is a mechanism …