Evaluation of pathological complete response as surrogate endpoint in neoadjuvant randomised clinical trials of early stage breast cancer: systematic review and …
Objective To evaluate pathological complete response as a surrogate endpoint for disease-
free survival and overall survival in regulatory neoadjuvant trials of early stage breast …
free survival and overall survival in regulatory neoadjuvant trials of early stage breast …
Disease-free survival as a surrogate for overall survival in adjuvant trials of gastric cancer: a meta-analysis
Background In investigations of the effectiveness of surgery and adjuvant chemotherapy for
gastric cancers, overall survival (OS) is considered the gold standard endpoint. However …
gastric cancers, overall survival (OS) is considered the gold standard endpoint. However …
Metastasis-free survival is a strong surrogate of overall survival in localized prostate cancer
Purpose Adjuvant therapy for intermediate-risk and high-risk localized prostate cancer
decreases the number of deaths from this disease. Surrogates for overall survival (OS) could …
decreases the number of deaths from this disease. Surrogates for overall survival (OS) could …
Springer series in statistics
The idea for this book came from the time the authors spent at the Statistics and Applied
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …
Springer Series in Statistics
Hidden Markov models—most often abbreviated to the acronym “HMMs”—are one of the
most successful statistical modelling ideas that have came up in the last forty years: the use …
most successful statistical modelling ideas that have came up in the last forty years: the use …
Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized …
DJ Sargent, HS Wieand, DG Haller, R Gray… - Journal of Clinical …, 2005 - ascopubs.org
Purpose A traditional end point for colon adjuvant clinical trials is overall survival (OS), with
5 years demonstrating adequate follow-up. A shorter-term end point providing convincing …
5 years demonstrating adequate follow-up. A shorter-term end point providing convincing …
Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of …
A Mauguen, JP Pignon, S Burdett, C Domerg… - The lancet …, 2013 - thelancet.com
Background The gold standard endpoint in clinical trials of chemotherapy and radiotherapy
for lung cancer is overall survival. Although reliable and simple to measure, this endpoint …
for lung cancer is overall survival. Although reliable and simple to measure, this endpoint …
[图书][B] The evaluation of surrogate endpoints
T Burzykowski, M Buyse, G Molenberghs - 2005 - Springer
Both humanitarian and commercial considerations have spurred intensive search for
methods to reduce the time and cost required to develop new therapies. The identification …
methods to reduce the time and cost required to develop new therapies. The identification …
Evaluation of tumor response, disease control, progression-free survival, and time to progression as potential surrogate end points in metastatic breast cancer
T Burzykowski, M Buyse, MJ Piccart-Gebhart… - Journal of Clinical …, 2008 - ascopubs.org
Purpose Overall survival (OS) can be observed only after prolonged follow-up, and any
potential effect of first-line therapies on OS may be confounded by the effects of subsequent …
potential effect of first-line therapies on OS may be confounded by the effects of subsequent …