The regulation of cellular function by hormones and extracellular molecules, which bind to
cell surface receptors, is initiated by signal transduction mech anisms at the plasma …

ABSTRACT H89 is marketed as a selective and potent inhibitor of protein kinase A (PKA).
Since its discovery, it has been used extensively for evaluation of the role of PKA in the …

LS Maier and DM Bers. Calcium, Calmodulin, and Calcium-Calmodulin Kinase II: Heartbeat
to Heartbeat and Beyond. Journal of Molecular and Cellular Cardiology (2002) 34, 919–939 …

Increases in heart rate are accompanied by acceleration of relaxation. This effect is apparent
at the single myocyte level and depends on sarcoplasmic reticulum (SR) Ca transport and …

Calcium (Ca) is a multifunctional regulator of diverse cellular functions. In cardiac muscle Ca
is a direct central mediator of electrical activation, ion channel gating, and excitation …

Previously, we reported that red blood cells (RBCs) of rabbits and humans release ATP in
response to mechanical deformation and that this release of ATP requires the activity of the …

Phospholamban (PLB) can be phosphorylated at Ser 16 by cyclic AMP-dependent protein
kinase and at Thr 17 by Ca 2+-calmodulin-dependent protein kinase during β-agonist …

Cardiac adaptation to aerobic exercise training includes improved cardiomyocyte
contractility and calcium handling. Our objective was to determine whether cytosolic …

Fluorescent Ca indicators have been extremely valuable in understanding intracellular
[Ca]([Ca] i) regulation in many cell types. The calibration of these indicators in the …

Insufficient sarco/endoplasmic reticulum calcium ATPase (SERCA) activity significantly
contributes to heart failure, which is a leading cause of death worldwide. A characteristic …