Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites,
including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and …

Millions of people worldwide lie at the risk of parasitic protozoic infections that kill over a
million people each year. The rising inefficacy of conventional therapeutics to combat these …

Background: Malaria parasites go through major transitions during their complex life cycle,
yet the underlying differentiation pathways remain obscure. Here we apply single cell …

Heme-biosynthetic pathway of malaria parasite is dispensable for asexual stages, but
essential for mosquito and liver stages. Despite having backup mechanisms to acquire …

Abstract Background The malaria parasite Plasmodium falciparum expresses four related
papain-family cysteine proteases known as falcipains. These proteases play critical roles in …

The circumsporozoite protein (CSP) is one of the most studied proteins of the malaria
parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite …

Malaria is a tropical disease with significant morbidity and mortality burden caused by
Plasmodium species in Africa, the Middle East, Asia, and South America. Pathogenic …

Background Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a
complication of malaria with a lethality rate of up to 80% despite anti-malarial treatment. It is …

Protein kinases uniquely expressed in Plasmodium represent attractive drug targets.
Previous studies have reported that Plasmodium falciparum Protein kinase 9 (Pk9) …

The pre-erythrocytic liver stage of the malaria parasite, comprising sporozoites and the liver
stages into which they develop, remains one of the least understood parts of the lifecycle, in …