Predictors of Complicated Disease Course in Adults and Children With Crohn's Disease: A Nationwide Study from the epi-IIRN

O Atia, R Lujan, R Buchuk, S Greenfeld… - Inflammatory Bowel …, 2024 - academic.oup.com
Background Since data on predictors of complicated Crohn's disease (CD) from unselected
populations are scarce, we aimed to utilize a large nationwide cohort, the epi-IIRN, to …

[HTML][HTML] Machine Learning and Statistical Shape Modelling Methodologies to Assess Vascular Morphology before and after Aortic Valve Replacement

Y Aljassam, F Sophocleous, JL Bruse, V Schot… - Journal of Clinical …, 2024 - mdpi.com
Introduction: Statistical shape modelling (SSM) is used to analyse morphology, discover
qualitatively and quantitatively unique shape features within a population, and generate …

Multi-Trait genetic analysis reveals clinically interpretable hypertension subtypes

F Vaura, H Kim, MS Udler, FinnGen*… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Hypertension comprises a heterogeneous range of phenotypes. We asked
whether underlying genetic structure could explain a part of this heterogeneity. Methods: Our …

Social and Metabolic Determinants of Prevalent Hypertension in Men and Women: A Cluster Analysis from a Population-Based Study

C Bala, A Rusu, OF Gheorghe-Fronea… - International Journal of …, 2023 - mdpi.com
Essential hypertension (HTN) has a complex spectrum of pathophysiological determinants
and current guidelines provide limited information on high-risk groups that should be …

Identification of Novel Metabolic Subtypes Using Multi-Trait Limited Mixed Regression in the Chinese Population

K Ding, Z Zhou, Y Ma, X Li, H Xiao, Y Wu, T Wu… - Biomedicines, 2022 - mdpi.com
The aggregation and interaction of metabolic risk factors leads to highly heterogeneous
pathogeneses, manifestations, and outcomes, hindering risk stratification and targeted …