Adipose-tissue plasticity in health and disease

A Sakers, MK De Siqueira, P Seale, CJ Villanueva - Cell, 2022 - cell.com
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

P Morigny, J Boucher, P Arner, D Langin - Nature Reviews …, 2021 - nature.com
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Adipose tissue at single-cell resolution

B Maniyadath, Q Zhang, RK Gupta, S Mandrup - Cell metabolism, 2023 - cell.com
Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Adipogenesis and metabolic health

AL Ghaben, PE Scherer - Nature reviews Molecular cell biology, 2019 - nature.com
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

[HTML][HTML] Dermal adipocyte lipolysis and myofibroblast conversion are required for efficient skin repair

BA Shook, RR Wasko, O Mano… - Cell Stem Cell, 2020 - cell.com
Mature adipocytes store fatty acids and are a common component of tissue stroma.
Adipocyte function in regulating bone marrow, skin, muscle, and mammary gland biology is …

Update on adipose tissue and cancer

KA Brown, PE Scherer - Endocrine reviews, 2023 - academic.oup.com
Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

[HTML][HTML] Adipocyte mesenchymal transition contributes to mammary tumor progression

Q Zhu, Y Zhu, C Hepler, Q Zhang, J Park, C Gliniak… - Cell reports, 2022 - cell.com
Obesity is associated with increased cancer incidence and progression. However, the
relationship between adiposity and cancer remains poorly understood at the mechanistic …

Low-and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

A Song, W Dai, MJ Jang, L Medrano… - The Journal of …, 2020 - Am Soc Clin Investig
Brown adipose tissue (BAT), as the main site of adaptive thermogenesis, exerts beneficial
metabolic effects on obesity and insulin resistance. BAT has been previously assumed to …

Endocrine role of bone in the regulation of energy metabolism

R Zhou, Q Guo, Y Xiao, Q Guo, Y Huang, C Li, X Luo - Bone research, 2021 - nature.com
Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

Insulin resistance and cancer: in search for a causal link

E Chiefari, M Mirabelli, S La Vignera… - International journal of …, 2021 - mdpi.com
Insulin resistance (IR) is a condition which refers to individuals whose cells and tissues
become insensitive to the peptide hormone, insulin. Over the recent years, a wealth of data …