Post-transcriptional regulation in multicellular organisms is mediated by microRNAs.
However, the principles that determine if a gene is regulated by miRNAs are poorly …

Non-coding RNAs play a key role in the post-transcriptional regulation of mRNA translation
and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through …

Background MicroRNAs are a class of short non-coding RNAs derived from either cellular or
viral transcripts that act post-transcriptionally to regulate mRNA stability and translation. In …

Gene expression is a noisy process and several mechanisms, both transcriptional and post-
transcriptional, can stabilize protein levels in cells. Much work has focused on the role of …

Comparisons of evolutionary features between human disease and non-disease genes
have a wide implication to understand the genetic basis of human disease genes. However …

In general, proteins do not work alone; they form macromolecular complexes to play
fundamental roles in diverse cellular functions. On the basis of their iterative clustering …

To date, numerous studies have been attempted to determine the extent of variation in
evolutionary rates between human disease and nondisease (ND) genes. In our present …

Identification of protein complexes is of great importance in the understanding of cellular
organization and functions. Traditional computational protein complex prediction methods …

Identification of protein complexes is of great importance in the understanding of cellular
organization and functions. Traditional computational protein complex prediction methods …