HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic
enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the …

Atypical antipsychotic drugs have revolutionized the treatment of schizophrenia and related
disorders. The current clinically approved atypical antipsychotic drugs are characterized by …

Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …

G-protein-coupled receptors (GPCRs) constitute a large and diverse family of proteins
whose primary function is to transduce extracellular stimuli into intracellular signals. They …

The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies
by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those …

The human polyomavirus, JCV, causes the fatal demyelinating disease progressive
multifocal leukoencephalopathy in immunocompromised patients. We found that the …