Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Axonal degeneration is an early and prominent feature of many neurological disorders.
SARM1 is the central executioner of the axonal degeneration pathway that culminates in …

Pathological degeneration of axons disrupts neural circuits and represents one of the
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …

Neuroinflammation and necroptosis are major contributors to neurodegenerative disease,
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …

Axon degeneration is a hallmark of many neurodegenerative disorders. The current
assumption is that the decision of injured axons to degenerate is cell-autonomously …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

The NADase SARM1 is a central switch in injury-activated axon degeneration, an early
hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo …

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …

Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD
pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical …