More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …

Cytokines signal through cell surface receptor dimers to initiate activation of intracellular
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …

Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now
known to represent a distinct member of the IFN family and plays critical roles not only in …

Castleman disease (CD), a heterogeneous group of disorders that share morphological
features, is divided into unicentric CD and multicentric CD (MCD) according to the clinical …

Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …

Abstract During SARS-CoV-2 infection, the innate immune response can be inhibited or
delayed, and the subsequent persistent viral replication can induce emergency signals that …