Since the first heart transplantation (HT) in 1967, survival has steadily improved. Issues
related to over-and under-immunosuppression are, however, still common following HT …

Renal dysfunction after heart transplantation is a frequently observed complication, in some
cases resulting in significant limitation of quality of life and reduced survival. Since the …

Acute renal failure (ARF) is a life-threatening complication after allogeneic stem cell
transplantation (Allo-HSCT). Identification of ARF risk factors could be useful to develop …

BACKGROUND: Cyclosporine nephrotoxicity negatively impacts long-term outcome after
heart transplantation (HT). We previously reported 1-year results from a randomized study …

Background In the last decade, mTOR inhibitors (mTOR-is) have become the cornerstone of
the calcineurin inhibitor (CNI)-reduced/free regimens aimed to the preservation of post …

Chinnock TJ, Shankel T, Deming D, Cutler D, Sahney S, Fitts J, Chinnock RE. Calcineurin
inhibitor minimization using sirolimus leads to improved renal function in pediatric heart …

BACKGROUND: Heart transplantation in the elderly is increasingly common. In the mid-
1990s, 25% of recipients in our program were> 62 years of age. We evaluated outcomes …

Matthews KL, Gossett J, Vande Kappelle P, Jellen G, Pahl E. Indications, tolerance and
complications of a sirolimus and calcineurin inhibitor immunosuppression regimen …

Background Sirolimus has been used increasingly in heart transplantation for its ability to
reduce acute rejection, prevent the progression of cardiac allograft vasculopathy (CAV), and …

Heart transplantation (HT) is the definitive treatment for eligible patients with end‐stage
heart disease. A major complication of HT is allograft rejection which can lead to graft …