The autoimmune reaction against the beta cells of the pancreatic islets in type 1 diabetes
mellitus (T1DM) patients is active in prediabetes and during the development of the clinical …

Numerous preclinical models have been developed to advance biomedical research in type
1 diabetes mellitus (T1DM). They are essential for improving our knowledge of T1DM …

Abstract Type 1 diabetes (T1D), which is a chronic autoimmune disease, results from the
destruction of insulin‐producing β cells targeted by autoreactive T cells. The recent …

Healing of chronic wounds such as diabetic foot ulcers is a critical clinical challenge due to
the failure management of excess exudates, persistent inflammatory responses, and …

Type 1 diabetes results from defects in immune self-tolerance that lead to inflammatory
infiltrate in pancreatic islets, beta cell dysfunction and T cell-mediated killing of beta cells …

Diabetic peripheral neuropathy (DPN) and diabetic osteoporosis (DOP) are conditions that
significantly impact the quality of life of patients worldwide. Rehmanniae Radix Preparata, a …

Diabetes is closely related to immune response problems when it occurs chronically.
Pegagan (Centella asiatica) is a medicinal plant with active compounds. Madecassoside is …

Norisoboldine (NOR), an alkaloid isolated from Radix Lindera, was previously reported to
promote the differentiation of regulatory T cells (Treg cells), an important subtype of …

Several aryl hydrocarbon receptor (AhR) agonists have been reported to promote the
generation of regulatory T cells (Treg cells), and the action mechanisms need to be …

Defining the immunological landscape of human tissue is an important area of research, but
challenges include the impact of tissue disaggregation on cell phenotypes and the low …