Triple negative breast cancer (TNBC) is a subtype of breast cancer with typically poorer
outcomes due to its aggressive clinical behavior and lack of targeted treatment options …

This study aimed to investigate metabolic changes following the acquisition of resistance to
doxorubicin in the triple-negative breast cancer (TNBC) cell line MDA-MB-231. Two drug …

Tobacco use is a major public health concern and is linked to myriad diseases, including
cancer. The link between tobacco use and oral cancer, specifically, is very strong, making …

Tumor cells generally require large amounts of nucleotides, and thus activate de novo
purine synthesis (dn PS). In the dn PS reactions, 10-formyltetrahydorofolate (10-fTHF) …

Folate (vitamin B9) is involved in one-carbon transfer reactions and plays a significant role in
nucleic acid synthesis and control of cellular proliferation, among other key cellular …

ALDH1L2, a mitochondrial enzyme in folate metabolism, converts 10‐formyl‐THF (10‐
formyltetrahydrofolate) to THF (tetrahydrofolate) and CO2. At the cellular level, deficiency of …

Abstract The Aldh1l1-Cre/ER T2 mouse is a widely used transgenic mouse model to
conditionally express Cre recombinase in astrocytes of the central nervous system …

Background: ALDH1L1 plays a crucial role in folate metabolism, regulating the flow of one-
carbon groups through the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and …