Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …

We summarize research approaches and findings on bone healing and regeneration that
were presented at a workshop at the 60th annual meeting of the Orthopedic Research …

Tissue engineering is a promising alternative to autografts or allografts for the regeneration
of large bone defects. Cell-free biomaterials with different degrees of sophistication can be …

Introduction: Drug toxicity often goes undetected until clinical trials, which are the most costly
and dangerous phase of drug development. Both the cultures of human cells and animal …

The production of veritable in-vitro models of bone tissue is essential to understand the
biology of bone and its surrounding environment, to analyze the pathogenesis of bone …

Introduction: A major hurdle in treating osteochondral (OC) defects is the different healing
abilities of two types of tissues involved–articular cartilage and subchondral bone …

Bone engineering makes it possible to grow unlimited amounts of viable tissue products for
basic and applied research, and for clinical applications. A common trend in tissue …

Articular cartilage repair techniques are challenging. Human embryonic stem cells and
induced pluripotent stem cells (iPSCs) theoretically provide an unlimited number of …

Abstract Bone metastases occur in 65%–80% advanced breast cancer patients. Although
significant progresses have been made in understanding the biological mechanisms driving …

Autologous bone marrow concentrate (BMC) and mesenchymal stem cells (MSCs) have
beneficial effects on the healing of bone defects. To address the shortcomings associated …