Although 5-fluorouracil (5-FU)-based chemotherapy is the major treatment for colorectal
cancer, it has disadvantages such as systemic toxicity, lack of effectiveness and selectivity …

The acquisition of cancer cell resistance to conventional chemotherapeutics is considered
the major driver of treatment failure and disease recurrence in most solid and hematological …

The targeted delivery of a drug should result in enhanced therapeutic efficacy with low to
minimal side effects. This is a widely accepted concept, but limited in application due to lack …

The inherent or induced resistance of tumors to cytostatic agents is a major clinical problem.
In this review, we summarize the pre-clinical mechanisms of acquired and inherent …

Artemisia annua L. is a Chinese medicinal plant, which is used throughout Asia and Africa
as tea or press juice to treat malaria. The bioactivity of its chemical constituent, artemisinin is …

We tested the ability of recombinant hMutSα (hMSH2/hMSH6) and hMutSβ (hMSH2/hMSH3)
heterodimers to complement the mismatch repair defect of HEC59, a human cancer cell line …

Our studies showed that an abundant folate enzyme, 10-
formyltetrahydrofolatedehydrogenase (FDH), is strongly down-regulated in several types of …

This article discusses the role of nucleoside transport processes in the cytotoxicity of
clinically important anticancer nucleosides. This article summarizes recent advances in the …

Background & Aims: Reg IV, a secreted protein and member of the Reg multigene family, is
up-regulated in malignancies of the human gastrointestinal tract, including colorectal …

Primary and secondary resistance to the widely used antimetabolite 5-fluorouracil (5-FU) are
common phenomena in cancer chemotherapy. Because 5-FU still remains the agent of …