Accessing the vasculature in cancer: revising an old hallmark
The classic cancer hallmark, inducing angiogenesis, was born out of the long-held notion
that tumours could grow only if new vessels were formed. The attempts, based on this …
that tumours could grow only if new vessels were formed. The attempts, based on this …
Histopathological growth pattern in colorectal liver metastasis and the tumor immune microenvironment
C Zaharia, T Veen, D Lea, A Kanani, M Alexeeva… - Cancers, 2022 - mdpi.com
Simple Summary Liver metastases occur in almost half of patients with colorectal cancer,
either at the time of presentation (synchronous) or eventually as a metachronous recurrence …
either at the time of presentation (synchronous) or eventually as a metachronous recurrence …
The molecular mechanisms underlying neutrophil infiltration in vessel co-opting colorectal cancer liver metastases
Colorectal cancer liver metastases (CRCLMs) have two major histopathological growth
patterns (HGPs): desmoplastic (DHGP) and replacement (RHGP). The DHGP tumours …
patterns (HGPs): desmoplastic (DHGP) and replacement (RHGP). The DHGP tumours …
The multifaceted role of PCSK9 in cancer pathogenesis, tumor immunity, and immunotherapy
CY Hsu, MN Abdulrahim, MA Mustafa, TM Omar… - Medical Oncology, 2024 - Springer
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a well-known regulator of cholesterol
metabolism and cardiovascular diseases, has recently garnered attention for its emerging …
metabolism and cardiovascular diseases, has recently garnered attention for its emerging …
A retrospective study on the role of metformin in colorectal cancer liver metastases
Colorectal cancer liver metastases (CRCLMs) have two main histopathological growth
patterns (HPGs): desmoplastic (DHGP) and replacement (RHGP). The vascularization in …
patterns (HPGs): desmoplastic (DHGP) and replacement (RHGP). The vascularization in …
High levels of serum cholesterol positively correlate with the risk of the development of vessel co-opting tumours in colorectal cancer liver metastases
M Rada, L Krzywon, A Kapelanski-Lamoureux… - MedRxiv, 2022 - medrxiv.org
Colorectal cancer liver metastatic (CRCLM) tumours present as two main histopathological
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
Inhibition of proprotein convertase subtilisin-like kexin type 9 (PCSK9) potentiates anti-angiogenic therapy in colorectal cancer liver metastases
Colorectal cancer liver metastatic (CRCLM) tumours present as two main histopathological
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
Vessel co-option: a unique vascular-immune niche in liver cancer
D Yang, S Dang, Z Wang, M Xie, X Li, X Ding - Frontiers in Oncology, 2024 - frontiersin.org
Tumor vasculature is pivotal in regulating tumor perfusion, immune cell infiltration,
metastasis, and invasion. The vascular status of the tumor is intricately linked to its immune …
metastasis, and invasion. The vascular status of the tumor is intricately linked to its immune …
The Inhibition of Vessel Co-Option as an Emerging Strategy for Cancer Therapy
I Carrera-Aguado, L Marcos-Zazo… - International Journal of …, 2024 - mdpi.com
Vessel co-option (VCO) is a non-angiogenic mechanism of vascularization that has been
associated to anti-angiogenic therapy. In VCO, cancer cells hijack the pre-existing blood …
associated to anti-angiogenic therapy. In VCO, cancer cells hijack the pre-existing blood …
Disruption of integrin alpha-5/beta-1-dependent transforming growth factor beta-1 signaling pathway attenuates vessel co-option in colorectal cancer liver metastases
Colorectal cancer liver metastases (CRCLM) have two major histopathological growth
patterns (HGPs) including angiogenic desmoplastic HGP (DHGP) and non-angiogenic …
patterns (HGPs) including angiogenic desmoplastic HGP (DHGP) and non-angiogenic …