The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
The current status of latency reversing agents for HIV-1 remission
A Rodari, G Darcis, CM Van Lint - Annual review of virology, 2021 - annualreviews.org
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
HIV silencing and cell survival signatures in infected T cell reservoirs
Rare CD4 T cells that contain HIV under antiretroviral therapy represent an important barrier
to HIV cure,–, but the infeasibility of isolating and characterizing these cells in their natural …
to HIV cure,–, but the infeasibility of isolating and characterizing these cells in their natural …
Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells
M Dube, O Tastet, C Dufour, G Sannier, N Brassard… - Cell Host & Microbe, 2023 - cell.com
Spontaneous transcription and translation of HIV can persist during suppressive
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …
Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir
Understanding the complexity of the long-lived HIV reservoir during antiretroviral therapy
(ART) remains a considerable impediment in research towards a cure for HIV. To address …
(ART) remains a considerable impediment in research towards a cure for HIV. To address …
Block-and-lock: new horizons for a cure for HIV-1
I Moranguinho, ST Valente - Viruses, 2020 - mdpi.com
HIV-1/AIDS remains a global public health problem. The world health organization (WHO)
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir
The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …
The multifaceted nature of HIV latency
C Dufour, P Gantner, R Fromentin… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants
Q Wang, C Yang, L Yin, J Sun, W Wang, H Li… - … and Targeted Therapy, 2023 - nature.com
The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the
effectiveness of currently licensed SARS-CoV-2 vaccines based on ancestral strains …
effectiveness of currently licensed SARS-CoV-2 vaccines based on ancestral strains …