Rural communities in developing countries lack access to affordable, reliable, and
sustainable forms of energy, which are essential factors for improving living conditions …

Most known disease-causing mutations occur in protein-coding regions of DNA. While some
of these involve a loss of protein function (eg, through premature stop codons or missense …

Approximately half of human genes generate mRNAs with alternative 3′ untranslated
regions (3′ UTRs). Through 3′ UTR-mediated protein-protein interactions, alternative 3 …

The study of cellular processes occurring inside intact organisms requires methods to
visualize cellular functions such as gene expression in deep tissues. Ultrasound is a widely …

Chloroplast translation is essential for cellular viability and plant development. Its positioning
at the intersection of organellar RNA and protein metabolism makes it a unique point for the …

The formation of protein complexes is crucial to most biological functions. The cellular
mechanisms governing protein complex biogenesis are not yet well understood, but some …

Cells dedicate significant energy to build proteins often organized in multiprotein assemblies
with tightly regulated stoichiometries. As genes encoding subunits assembling in a …

Cells tightly regulate mRNA processing, localization, and stability to ensure accurate gene
expression in diverse cellular states and conditions. Most of these regulatory steps have …

Disulfide bonds are an abundant feature of proteins across all domains of life that are
important for structure, stability, and function. In eukaryotic cells, a major site of disulfide …

The faithful assembly of protein complexes in space and time is a hallmark of cellular
homeostasis. Complex assembly might be seeded already during translation, if interacting …