Due to the continued emergence of resistance and a lack of new and promising antibiotics,
bacterial infection has become a major public threat. High-throughput screening (HTS) …

Tuberculosis (TB) is the second leading cause of human mortality from infectious diseases
worldwide. The WHO reported 1.3 million deaths and 8.6 million new cases of TB in 2012 …

A previously described aryl sulfonamide series, originally found through HTS, targets GlmU,
a bifunctional essential enzyme involved in bacterial cell wall synthesis. Using structure …

The synthesis of the bacterial peptidoglycan has been recognized for over 50 years as fertile
ground for antibacterial discovery. Initially, empirical screening of natural products for …

M. tuberculosis N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmUMtb) is a bi-
functional enzyme engaged in the synthesis of two metabolic intermediates N …

GlmM and GlmU are key enzymes in the biosynthesis of UDP-N-acetyl-d-glucosamine (UDP-
GlcNAc), an essential precursor of peptidoglycan and the rhamnose–GlcNAc linker region in …

Due to the inexorable invasion of our hospitals and communities by drug-resistant bacteria,
there is a pressing need for novel antibacterial agents. Here we report the development of a …

A high-throughput screen led to the discovery of 2-amino-4-oxo-4-phenylbutanoate
inhibitors of the 1, 4-dihydroxy-2-naphthoyl-CoA synthase (MenB) from the menaquinone …

Several decades after the discovery of the first antibiotic (penicillin) microbes have evolved
novel mechanisms of resistance; endangering not only our abilities to combat future …

In the past five years, an alarming increase in the number of patients with multidrug resistant
tuberculosis (MDR TB) and extensively drug-resistant tuberculosis (XDR TB) has been …