Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Availability of key nutrients, such as sugars, amino acids, and nitrogen compounds, dictates
the developmental programs and the growth rates of yeast cells. A number of overlapping …

▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …

Intracellular energy balance is important for cell survival. In eukaryotic cells, the most energy-
consuming process is ribosome biosynthesis, which adapts to changes in intracellular …

Genes encoding rRNA are multicopy and thus could be regulated by changing the number
of active genes or by changing the transcription rate per gene. We tested the hypothesis that …

The preferred source of carbon and energy for yeast cells is glucose. When yeast cells are
grown in liquid cultures, they metabolize glucose predominantly by glycolysis, releasing …

In the extensive network of interdependent biochemical processes required for cell growth
and division, there is mounting evidence that ribosomal DNA transcription by RNA …

Eukaryotes regulate the effective dosage of their ribosomal RNA (rRNA) genes, expressing
fewer than half of the genes at any one time. Likewise, genetic hybrids displaying nucleolar …

The genes that encode ribosomal RNA exist in two distinct types of chromatin—
an'open'conformation that is permissive to transcription and a'closed'conformation that is …

Histone acetylation depends on intermediary metabolism for supplying acetyl-CoA in the
nucleocytosolic compartment. However, because nucleocytosolic acetyl-CoA is also used …