Why the HIV reservoir never runs dry: clonal expansion and the characteristics of HIV-infected cells challenge strategies to cure and control HIV infection
CY Lau, MA Adan, F Maldarelli - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy
J Blazkova, F Gao, MH Marichannegowda… - Nature Medicine, 2021 - nature.com
Certain infected individuals suppress human immunodeficiency virus (HIV) in the absence of
anti-retroviral therapy (ART). Elucidating the underlying mechanism (s) is of high interest …
anti-retroviral therapy (ART). Elucidating the underlying mechanism (s) is of high interest …
Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells
C Passaes, D Desjardins, A Chapel… - Nature …, 2024 - nature.com
HIV remission can be achieved in some people, called post-treatment HIV controllers, after
antiretroviral treatment discontinuation. Treatment initiation close to the time of infection was …
antiretroviral treatment discontinuation. Treatment initiation close to the time of infection was …
Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells
H Takata, JC Kakazu, JL Mitchell, E Kroon, DJ Colby… - …, 2022 - thelancet.com
Summary Background Harnessing CD8+ T cell responses is being explored to achieve HIV
remission. Although HIV-specific CD8+ T cells become dysfunctional without treatment …
remission. Although HIV-specific CD8+ T cells become dysfunctional without treatment …
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART)
interruption are urgently needed. Such biomarkers can improve the safety of analytic …
interruption are urgently needed. Such biomarkers can improve the safety of analytic …
Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in …
M Calvet-Mirabent, I Sánchez-Cerrillo… - …, 2022 - thelancet.com
Summary Background Dysfunction of CD8+ T cells in people living with HIV-1 (PLWH)
receiving anti-retroviral therapy (ART) has restricted the efficacy of dendritic cell (DC)-based …
receiving anti-retroviral therapy (ART) has restricted the efficacy of dendritic cell (DC)-based …
Novel approaches towards a functional cure of HIV/AIDS
Therapeutic approaches towards a functional cure or eradication of HIV have gained
renewed momentum upon encouraging data emerging from studies in SIV monkey models …
renewed momentum upon encouraging data emerging from studies in SIV monkey models …
Efficient treatment and pre-exposure prophylaxis in rhesus macaques by an HIV fusion-inhibitory lipopeptide
J Xue, H Chong, Y Zhu, J Zhang, L Tong, J Lu, T Chen… - Cell, 2022 - cell.com
Two HIV fusion-inhibitory lipopeptides (LP-97 and LP-98) were designed with highly potent,
long-acting antiviral activity. Monotherapy using a low dose of LP-98 sharply reduced viral …
long-acting antiviral activity. Monotherapy using a low dose of LP-98 sharply reduced viral …
Prevalence of HIV-1 infection and associated characteristics in a Brazilian indigenous population: a cross-sectional study
ECS Schnaufer, MS Barbosa, MFR Marques… - The Lancet Regional …, 2023 - thelancet.com
Background Despite significant progress in the areas of prevention, diagnosis, and
treatment, HIV continues to result in a substantial number of fatalities on a global scale each …
treatment, HIV continues to result in a substantial number of fatalities on a global scale each …