Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …

Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …

Background Middle-and long-distance running performance is constrained by several
important aerobic and anaerobic parameters. The efficacy of strength training (ST) for …

Mutations in either the TSC1 or TSC2 tumor suppressor gene are responsible for Tuberous
Sclerosis Complex. The gene products of TSC1 and TSC2 form a functional complex and …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …