Chemokines, binding their various G protein-coupled receptors, lead the way for leukocytes
in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes …

B cell receptor (BCR) signaling plays an important pathogenic role in chronic lymphocytic
leukemia (CLL) and B cell lymphomas, based on structural restrictions of the BCR, and BCR …

Duvelisib (also known as IPI-145) is an oral, dual inhibitor of phosphatidylinositol 3-kinase δ
and γ (PI3K-δ, γ) being developed for treatment of hematologic malignancies. PI3K-δ, γ …

Receptor for activated C kinase 1 (RACK1) has been shown to promote oral squamous cell
carcinoma (OSCC) progression, and RACK1 expression levels have been negatively …

Purpose: Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental
interactions for proliferation and survival that are at least partially mediated through B-cell …

Chemokines are a group of low molecular weight peptides. Their major function is the
recruitment of leukocytes to inflammation sites, but they also play a key role in tumor growth …

The Bruton's tyrosine kinase inhibitor ibrutinib is a highly effective, new targeted therapy for
chronic lymphocytic leukemia (CLL) that thwarts leukemia cell survival, growth, and tissue …

Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor
suppressing functions. We reviewed the literature on correlations between IL-17 versus …

Purpose A phase 3 randomized study (COG ANBL0032) demonstrated significantly
improved outcome by adding immunotherapy with ch14. 18 antibody to isotretinoin as post …

Cancer pathogenesis involves the interplay of tumor-and microenvironment-derived stimuli.
Here we focused on the influence of an immunomodulatory cell type, myeloid-derived …