Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut
A fundamental and unresolved question in regenerative biology is how tissues return to
homeostasis after injury. Answering this question is essential for understanding the …
homeostasis after injury. Answering this question is essential for understanding the …
Peeling back the layers of lymph gland structure and regulation
During the past 60 years, the fruit fly, Drosophila melanogaster, has proven to be an
excellent model to study the regulation of hematopoiesis. This is not only due to the …
excellent model to study the regulation of hematopoiesis. This is not only due to the …
Maintenance of hematopoietic stem cell niche homeostasis requires gap junction–mediated calcium signaling
Regulation of stem cells requires coordination of the cells that make up the stem cell niche.
Here, we describe a mechanism that allows communication between niche cells to …
Here, we describe a mechanism that allows communication between niche cells to …
Immune cells and inflammatory mediators cause endothelial dysfunction in a vascular microphysiological system
A Rengarajan, HE Goldblatt, DJ Beebe… - Lab on a Chip, 2024 - pubs.rsc.org
Functional assessment of endothelium serves as an important indicator of vascular health
and is compromised in vascular disorders including hypertension, atherosclerosis, and …
and is compromised in vascular disorders including hypertension, atherosclerosis, and …
Cell cycle controls long-range calcium signaling in the regenerating epidermis
Skin homeostasis is maintained by stem cells, which must communicate to balance their
regenerative behaviors. Yet, how adult stem cells signal across regenerative tissue remains …
regenerative behaviors. Yet, how adult stem cells signal across regenerative tissue remains …
Formation of recurring transient Ca2+-based intercellular communities during Drosophila hematopoiesis
SB David, KYL Ho, G Tanentzapf… - Proceedings of the …, 2024 - National Acad Sciences
Tissue development occurs through a complex interplay between many individual cells. Yet,
the fundamental question of how collective tissue behavior emerges from heterogeneous …
the fundamental question of how collective tissue behavior emerges from heterogeneous …
Kinetics of blood cell differentiation during hematopoiesis revealed by quantitative long-term live imaging
Stem cells typically reside in a specialized physical and biochemical environment that
facilitates regulation of their behavior. For this reason, stem cells are ideally studied in …
facilitates regulation of their behavior. For this reason, stem cells are ideally studied in …
Ca2+ dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide
Background Cardiac mesenchymal stromal cells (C-MSC) were recently shown to
differentiate into adipocytes and myofibroblasts to promote the aberrant remodeling of …
differentiate into adipocytes and myofibroblasts to promote the aberrant remodeling of …
Gap-junction-mediated bioelectric signaling required for slow muscle development and function in zebrafish
RM Lukowicz-Bedford, JS Eisen, AC Miller - Current Biology, 2024 - cell.com
Bioelectric signaling, intercellular communication facilitated by membrane potential and
electrochemical coupling, is emerging as a key regulator of animal development. Gap …
electrochemical coupling, is emerging as a key regulator of animal development. Gap …
Biophysical control of plasticity and patterning in regeneration and cancer
NJ Murugan, S Cariba, S Abeygunawardena… - Cellular and Molecular …, 2024 - Springer
Cells and tissues display a remarkable range of plasticity and tissue-patterning activities that
are emergent of complex signaling dynamics within their microenvironments. These …
are emergent of complex signaling dynamics within their microenvironments. These …