Among the defining features of the animal kingdom is the ability of cells to change shape
and move. This underlies embryonic and postembryonic development, tissue homeostasis …

Mechanotransduction at cell–cell adhesions is crucial for the structural integrity,
organization, and morphogenesis of epithelia. At cell–cell junctions, ternary E-cadherin/β …

For multiple intracellular bacterial pathogens, the ability to spread directly into adjacent
epithelial cells is an essential step for disease in humans. For pathogens such as Shigella …

The cytoplasmic tails of classical cadherins form a multiprotein cadherin–catenin complex
(CCC) that constitutes the major structural unit of adherens junctions (AJs). The CCC in AJs …

Attachment between cells is crucial for almost all aspects of the life of cells. These inter-cell
adhesions are mediated by the binding of transmembrane cadherin receptors of one cell to …

The cadherin–catenin adhesion complex is the central component of the cell–cell adhesion
adherens junctions that transmit mechanical stress from cell to cell. We have determined the …

The regulation of cell–cell junctions during epidermal morphogenesis ensures tissue
integrity, a process regulated by α-catenin. This cytoskeletal protein connects the cadherin …

Abstract Adherens Junctions (AJs) are cell-cell adhesion complexes that sense and
propagate mechanical forces by coupling cadherins to the actin cytoskeleton via β-catenin …

As the core component of the adherens junction in cell–cell adhesion, the cadherin–catenin
complex transduces mechanical tension between neighboring cells. Structural studies have …

Abstract α-Catenin plays a critical role in tissue integrity, repair, and embryonic
development. However, the post-translational modifications of α-catenin and the correlative …