Nucleotide biosynthesis: the base of bacterial pathogenesis
Most free-living organisms require the synthesis and/or acquisition of purines and
pyrimidines, which form the basis of nucleotides, to survive. In most bacteria, the nucleotides …
pyrimidines, which form the basis of nucleotides, to survive. In most bacteria, the nucleotides …
Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages
JH Jiang, DR Cameron, C Nethercott… - Clinical microbiology …, 2023 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …
[HTML][HTML] MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation
The epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-
MRSA) USA300 lineage has recently become a leading cause of hospital-associated …
MRSA) USA300 lineage has recently become a leading cause of hospital-associated …
[HTML][HTML] Impact of the pentose phosphate pathway on metabolism and pathogenesis of Staphylococcus aureus
Staphylococcus aureus is an important pathogen that leads to significant disease through
multiple routes of infection. We recently published a transposon sequencing (Tn-seq) screen …
multiple routes of infection. We recently published a transposon sequencing (Tn-seq) screen …
Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics
AC Nolan, MS Zeden, I Kviatkovski, C Campbell… - Mbio, 2023 - Am Soc Microbiol
The purine-derived signaling molecules c-di-AMP and (p) ppGpp control mecA/PBP2a-
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections
During severe infections, Staphylococcus aureus moves from its colonising sites to blood
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …
[HTML][HTML] Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam …
Central metabolic pathways control virulence and antibiotic resistance, and constitute
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators, and role in key physiological response
S Poudel, H Tsunemoto, Y Seif… - Proceedings of the …, 2020 - National Acad Sciences
The ability of Staphylococcus aureus to infect many different tissue sites is enabled, in part,
by its transcriptional regulatory network (TRN) that coordinates its gene expression to …
by its transcriptional regulatory network (TRN) that coordinates its gene expression to …
The nucleotide messenger (p)ppGpp is an anti-inducer of the purine synthesis transcription regulator PurR in Bacillus
BW Anderson, MA Schumacher, J Yang… - Nucleic Acids …, 2022 - academic.oup.com
The nucleotide messenger (p) ppGpp allows bacteria to adapt to fluctuating environments by
reprogramming the transcriptome. Despite its well-recognized role in gene regulation,(p) …
reprogramming the transcriptome. Despite its well-recognized role in gene regulation,(p) …
[HTML][HTML] Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in
mammals and conceivably compete for space and nutrients. Here, we report that a …
mammals and conceivably compete for space and nutrients. Here, we report that a …