Mechanical regulation of bone remodeling

L Wang, X You, L Zhang, C Zhang, W Zou - Bone research, 2022 - nature.com
Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Update on the effects of microgravity on the musculoskeletal system

OJ Juhl IV, EG Buettmann, MA Friedman… - npj …, 2021 - nature.com
With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

The effects of microgravity on bone structure and function

J Man, T Graham, G Squires-Donelly, AL Laslett - npj Microgravity, 2022 - nature.com
Humans are spending an increasing amount of time in space, where exposure to conditions
of microgravity causes 1–2% bone loss per month in astronauts. Through data collected …

Using space-based investigations to inform cancer research on Earth

JL Becker, GR Souza - Nature Reviews Cancer, 2013 - nature.com
Experiments conducted in the microgravity environment of space are not typically at the
forefront of the mind of a cancer biologist. However, space provides physical conditions that …

The effects of weightlessness on the human organism and mammalian cells

J Pietsch, J Bauer, M Egli, M Infanger… - Current molecular …, 2011 - ingentaconnect.com
It has always been a desire of mankind to conquest Space. A major step in realizing this
dream was the completion of the International Space Station (ISS). Living there for several …

Biofabrication of in situ Self Assembled 3D Cell Cultures in a Weightlessness Environment Generated using Magnetic Levitation

M Anil-Inevi, S Yaman, AA Yildiz, G Mese… - Scientific reports, 2018 - nature.com
Magnetic levitation though negative magnetophoresis is a novel technology to simulate
weightlessness and has recently found applications in material and biological sciences. Yet …

Bisphosphonate conjugation enhances the bone-specificity of NELL-1-based systemic therapy for spaceflight-induced bone loss in mice

P Ha, JH Kwak, Y Zhang, J Shi, L Tran, TP Liu… - npj …, 2023 - nature.com
Microgravity-induced bone loss results in a 1% bone mineral density loss monthly and can
be a mission critical factor in long-duration spaceflight. Biomolecular therapies with dual …

Microgravity and musculoskeletal health: what strategies should be used for a great challenge?

R Bonanni, I Cariati, M Marini, U Tarantino, V Tancredi - Life, 2023 - mdpi.com
Space colonization represents the most insidious challenge for mankind, as numerous
obstacles affect the success of space missions. Specifically, the absence of gravitational …

Melatonin is a potential drug for the prevention of bone loss during space flight

M Ikegame, A Hattori, MJ Tabata… - Journal of pineal …, 2019 - Wiley Online Library
Astronauts experience osteoporosis‐like loss of bone mass because of microgravity
conditions during space flight. To prevent bone loss, they need a riskless and antiresorptive …

Induction of three-dimensional assembly and increase in apoptosis of human endothelial cells by simulated microgravity: impact of vascular endothelial growth factor

M Infanger, P Kossmehl, M Shakibaei, S Baatout… - Apoptosis, 2006 - Springer
Endothelial cells play a crucial role in the pathogenesis of many diseases and are highly
sensitive to low gravity conditions. Using a three-dimensional random positioning machine …