2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943

PK Mykhailiuk - Chemical Reviews, 2020 - ACS Publications
2, 2, 2-Trifluorodiazoethane (CF3CHN2) has been proven to be a valuable reagent for the
rapid synthesis of various classes of trifluoromethyl-substituted organic molecules in both …

An update on the progress of cycloaddition reactions of 3-methyleneindolinones in the past decade: versatile approaches to spirooxindoles

R Saeed, AP Sakla, N Shankaraiah - Organic & Biomolecular …, 2021 - pubs.rsc.org
Cycloaddition reactions are of great interest due to their potential and rapid construction of
optically enriched spiro-cyclic products. 3-Methyleneindolinones have been proven to be a …

Trifluorodiazoethane: A versatile building block to access trifluoromethylated heterocycles

A Kumar, WA Khan, S Ahamad… - Journal of Heterocyclic …, 2022 - Wiley Online Library
Trifluoromethylated heterocycles have attracted remarkable interest in the last decades. The
beneficial physicochemical and biological properties imparted by the incorporation of …

Trapping of Arynes with In Situ Generated Aryltrifluoromethylnitrones Enables Access to Trifluoromethylated Benzoxazolines

MF Jamali, M Ahmad, SP Chandrasekharan… - Organic …, 2023 - ACS Publications
Herein, we report a rare example of trapping arynes using in situ generated
aryltrifluoromethylnitrone to access an important class of trifluoromethylated benzoxazolines …

Synthesis of highly functionalized 12-membered trifluoromethyl heterocycles via a nondecarboxylative Pd-catalyzed [6+ 6] annulation

H Uno, T Imai, K Harada, N Shibata - ACS Catalysis, 2020 - ACS Publications
An efficient method for the construction of 12-membered heterocycles with a trifluoromethyl
group (3) was achieved via a nondecarboxylative Pd-catalyzed [6+ 6] annulation of six …

Synthesis of isoxazolidines via catalyst-free one-pot three-component cycloaddition of sulfoxonium ylides, nitrosoarenes and alkenes

X Li, P Zhai, Y Fang, W Li, H Chang… - Organic Chemistry …, 2021 - pubs.rsc.org
A general and practical strategy for the construction of various keto-substituted
isoxazolidines via one-pot three-component reaction of easily accessible, safer and more …

Hydrazones as Substrates in the Synthesis of Isoxazolidines via a KOH-Promoted One-Pot Three-Component Cycloaddition with Nitroso Compounds and Olefins

P Zhai, W Li, J Lin, X Li, WL Wei… - The Journal of Organic …, 2021 - ACS Publications
Hydrazones have been employed as the starting materials in a KOH-mediated one-pot three-
component cycloaddition with readily accessible nitroso compounds and olefins to construct …

Spiro‐2‐oxindoles via 1,3‐dipolar cycloadditions. A decade update

G Molteni, A Silvani - European Journal of Organic Chemistry, 2021 - Wiley Online Library
The great variety of spirooxindole three‐dimensional scaffolds encompasses relevant
bioactive natural alkaloids as well as useful therapeutic agents. In view of the challenging …

Silver-catalyzed direct synthesis of trifluoromethylated enaminopyridines and isoquinolinones employing trifluorodiazoethane

A Kumar, A Dhami, J Fairoosa, R Kant… - Organic Letters, 2021 - ACS Publications
This Letter reports a Ag-catalyzed three-component approach for the N-alkenylation of 2-
aminopyridines employing aldehydes and trifluorodiazoethane. Unlike the known reactions …

Metal‐free Reaction of Allenamides with In‐Situ Formed Trifluoromethylnitrones as a Route to Highly Functionalized Isoxazolidines

U Yadav, SP Chandrasekharan, PP Nair… - Asian Journal of …, 2023 - Wiley Online Library
An additive‐free three‐component reaction of allenamides with in situ generated
trifluoromethylnitrones has been uncovered. The reaction afforded an interesting class of …