Identification of potential inhibitors of SARS-COV-2 endoribonuclease (EndoU) from FDA approved drugs: a drug repurposing approach to find therapeutics for COVID …
SARS-CoV-2 is causative agent of COVID-19, which is responsible for severe social and
economic disruption globally. Lack of vaccine or antiviral drug with clinical efficacy …
economic disruption globally. Lack of vaccine or antiviral drug with clinical efficacy …
The significance of persisters in tuberculosis drug discovery: Exploring the potential of targeting the glyoxylate shunt pathway
The significant challenge in confronting TB eradication is the discursive treatment that
results in the disease reactivation, patient non compliance and drug resistance. The …
results in the disease reactivation, patient non compliance and drug resistance. The …
Transcriptomic analysis reveals key genes regulating organic acid synthesis and accumulation in the pulp of Litchi chinensis Sonn. cv. Feizixiao
L Hai-zhi, L Xiao-kai, D Jing-jia, P Jun-jie… - Scientia Horticulturae, 2022 - Elsevier
To investigate the gene expression characteristics and patterns of organic acid synthesis
and accumulation in the pulp of Litchi chinensis Sonn. cv. Feizixiao (FZX), 16-year-old …
and accumulation in the pulp of Litchi chinensis Sonn. cv. Feizixiao (FZX), 16-year-old …
Moonlighting proteins: beacon of hope in era of drug resistance in bacteria
Moonlighting proteins (MLPs) are ubiquitous and provide a unique advantage to bacteria
performing multiple functions using the same genomic content. Targeting MLPs can be …
performing multiple functions using the same genomic content. Targeting MLPs can be …
Bacterial protein azurin and derived peptides as potential anti-SARS-CoV-2 agents: insights from molecular docking and molecular dynamics simulations
The current pandemic SARS-CoV-2 has wreaked havoc in the world, and neither drugs nor
vaccine is available for the treatment of this disease. Thus, there is an immediate need for …
vaccine is available for the treatment of this disease. Thus, there is an immediate need for …
Mechanistic insights on nsSNPs on binding site of renin and cytochrome P450 proteins: A computational perceptual study for pharmacogenomics evaluation
L Loganathan, BB Kuriakose, S Mushfiq… - Journal of Cellular …, 2021 - Wiley Online Library
Past several decades, therapeutic investigations lead to the discovery of numerous
antihypertensive drugs. Although it has been proved for their potency, altered efficacy is …
antihypertensive drugs. Although it has been proved for their potency, altered efficacy is …
Identification of small molecules against the NMDAR: an insight from virtual screening, density functional theory, free energy landscape and molecular dynamics …
Alzheimer's disease (AD) is a chronic intensifying neurodegenerative disorder and accounts
for three fourths of dementia cases. To date, there is no effective treatment available which …
for three fourths of dementia cases. To date, there is no effective treatment available which …
Molecular Dynamics Simulation to Study Protein Conformation and Ligand Interaction
The field of molecular dynamics (MD) simulations has become indispensable today to
studying the conformational flexibility and dynamics of proteins as well as protein–ligand …
studying the conformational flexibility and dynamics of proteins as well as protein–ligand …
Role of structural biology methods in drug discovery
F Nasim, IA Qureshi - Advances in Protein Molecular and Structural Biology …, 2022 - Elsevier
The modern-age drug discovery revolves around the use of multiple high-resolution
structural biology methods. Over the years, these methods led to the genesis of some of the …
structural biology methods. Over the years, these methods led to the genesis of some of the …
Itaconate: an antimicrobial metabolite of macrophages
D Duncan, K Auclair - Canadian Journal of Chemistry, 2022 - cdnsciencepub.com
Itaconate is a conjugated 1, 4-dicarboxylate produced by macrophages. This small molecule
has recently received increasing attention due to its role in modulating the immune response …
has recently received increasing attention due to its role in modulating the immune response …