Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

Pyrazole and its derivatives are considered a privileged N-heterocycle with immense
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …

The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

GSK‐3 is a ubiquitously expressed serine/threonine kinase existing as GSK‐3α and GSK‐
3β isoforms, both active under basal conditions and inactivated upon phosphorylation by …

Neurodegenerative diseases are among the most challenging diseases with poorly known
mechanism of cause and paucity of complete cure. Out of all the neurodegenerative …

Abstract Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …

Neurodegenerative disorders are spreading worldwide and are one of the greatest threats to
public health. There is currently no adequate therapy for these disorders, and therefore there …

Abstract Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase which is
ubiquitously expressed and is regarded as a regulator for various cellular events and …

1. INTRODUCTION Nitrogen-containing heterocycles are widely distributed in nature and
essential for life, playing a vital role in the metabolism of all living cells. Among the many …

Pleiotropic intervention has prominent advantages for complex pathomechanisms, such as
Alzheimer's disease (AD). In this study, a series of novel 3-(4-pyridyl)-5-(4-sulfamido-phenyl) …