Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Opium poppy (Papaver somniferum) is one of the world's oldest medicinal plants and
remains the only commercial source for the narcotic analgesics morphine, codeine and semi …

The asymmetric synthesis of allylic amines is an important research area in modern
synthetic organic chemistry, primarily due to the inherent utility and ubiquity of this functional …

The biosynthesis of thebaine is based on the regioselective, intramolecular, oxidative
coupling of (R)‐reticuline. For decades, chemists have sought to mimic this coupling by …

A fully regio-and diastereoselective electrochemical 4a–2′-coupling of a 3′, 4′, 5′-
trioxygenated laudanosine derivative enables the synthesis of the corresponding …

This review summarizes recent developments in the total synthesis of morphine alkaloids
and some of the semisynthetic derivatives. The literature is covered for the period of 5 years …

Electrochemical techniques have helped to enable the total synthesis of natural products
since the pioneering work of Kolbe in the mid 1800's. The electrochemical toolset grows …

Our novel synthetic route to (−)-oxycodone, a semisynthetic opioid analgesic, features a
palladium-catalyzed direct intramolecular arylation of an aryl bromide, oxidative …

N‐Demethylation of oxycodone is one of the key steps in the synthesis of important opioid
antagonists like naloxone or analgesics like nalbuphine. The reaction is typically carried out …

Tertiary dialkylated allylic stereogenic centers are widespread substructures in bioactive
molecules and natural products. However, enantioselective access to dialkyl substituted …