Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies

KA Jellinger - Journal of neural transmission, 2018 - Springer
Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …

Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?

KA Jellinger, AD Korczyn - BMC medicine, 2018 - Springer
Abstract Background Dementia with Lewy bodies (DLB) and Parkinson's disease dementia
(PDD), which share many clinical, neurochemical, and morphological features, have been …

Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study

CB Hassen, A Fayosse, B Landré, M Raggi… - bmj, 2022 - bmj.com
Objective To examine the association of midlife and late life multimorbidity, including
severity of multimorbidity, with incident dementia. Design Prospective cohort study. Setting …

A comprehensive atlas of E3 ubiquitin ligase mutations in neurological disorders

AJ George, YC Hoffiz, AJ Charles, Y Zhu… - Frontiers in …, 2018 - frontiersin.org
Protein ubiquitination is a posttranslational modification that plays an integral part in
mediating diverse cellular functions. The process of protein ubiquitination requires an …

The role of mirror mechanism in the recovery, maintenance, and acquisition of motor abilities

G Rizzolatti, M Fabbri-Destro, A Nuara, R Gatti… - Neuroscience & …, 2021 - Elsevier
While it is well documented that the motor system is more than a mere implementer of motor
actions, the possible applications of its cognitive side are still under-exploited, often …

Disease progression in Parkinson subtypes: the PPMI dataset

D Aleksovski, D Miljkovic, D Bravi, A Antonini - Neurological Sciences, 2018 - Springer
Introduction Discrete patterns of progression have been suggested for patients with
Parkinson disease and presenting tremor dominant (TD) or postural instability gait disorders …

[HTML][HTML] Exercise-and strategy-based physiotherapy-delivered intervention for preventing repeat falls in people with Parkinson's: the PDSAFE RCT.

A Ashburn, R Pickering, E McIntosh… - Health Technology …, 2019 - ncbi.nlm.nih.gov
BACKGROUND People with Parkinson's disease are twice as likely to experience a fall as a
healthy older person, often leading to debilitating effects on confidence, activity levels and …

Cognitive impairment and dementia in Parkinson disease

JG Goldman, E Sieg - Clinics in geriatric medicine, 2020 - geriatric.theclinics.com
Cognitive impairment is a frequent nonmotor symptom in Parkinson disease (PD), often
associated with poor outcomes and reduced quality of life. 1–3 Cognitive impairment in PD …

Toward objective monitoring of Parkinson's disease motor symptoms using a wearable device: wearability and performance evaluation of PDMonitor®

A Antonini, H Reichmann, G Gentile, M Garon… - Frontiers in …, 2023 - frontiersin.org
Parkinson's disease (PD) is characterized by a variety of motor and non-motor symptoms. As
disease progresses, fluctuations in the response to levodopa treatment may develop, along …