Human NK cells can be subdivided into various subsets based on the relative expression of
CD16 and CD56. In particular, CD56 bright CD16−/dim NK cells are the focus of interest …

The heterogeneity in the healthy human immune system, and the immunological changes
that portend various diseases, have been only partially described. Their comprehensive …

Systems approaches have been used to describe molecular signatures driving immunity to
influenza vaccination in humans. Whether such signatures are similar across multiple …

HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …

Increased levels of total tumor-infiltrating lymphocytes (TILs) are generally associated with
good prognosis in several breast cancer subtypes. Subtypes of TILs impact both tumor cells …

Two human natural killer (NK) cell subsets are usually distinguished, displaying the
CD56dimCD16+ and the CD56brightCD16−/+ phenotype. This distinction is based on NK …

Administration of posttransplant cyclophosphamide (PTCy) has significantly expanded the
number of patients undergoing HLA-haploidentical hematopoietic cell transplantation (haplo …

NK cells are capable of an array of functions that range widely from their classic anti-tumor
and anti-viral cytotoxic effector functions, to their critical regulatory roles in controlling …

Cancer immunotherapies have gained significant momentum over the past decade,
particularly with the advent of checkpoint inhibitors and CAR T-cells. While the latter …

Constitutive heterozygous GATA2 mutation is associated with deafness, lymphedema,
mononuclear cytopenias, infection, myelodysplasia (MDS), and acute myeloid leukemia. In …