Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …

The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated
protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells …

Over the last decade important advances have been made in our understanding of the
molecular events underlying cellular responses to extracellular signals. Increased …

TAK1, a member of the mitogen-activated kinase kinase kinase (MAPKKK) family,
participates in proinflammatory cellular signaling pathways by activating JNK/p38 MAPKs …

Mitogen-activated protein kinases [MAPKs, also called extracellular signal-regulated
kinases (ERKs)] are constituents of numerous signal transduction pathways, and are …

Abstract The Ras-dependent Raf/MEK/ERK1/2 mitogen-activated protein (MAP) kinase
signaling pathway is a major regulator of cell proliferation and survival. Not surprisingly …

A series of alterations in the cellular genome affecting the expression or function of genes
controlling cell growth and differentiation is considered to be the main cause of cancer …

Periodontal disease initiation and progression occurs as a consequence of the host immune
inflammatory response to oral pathogens. Periodontal pathogens produce harmful by …

Aberrant activation of the three-layered protein kinase cascade, Raf/MEK/ERK, is often
detected in human cancer, which is mainly attributed to the oncogenic alterations of RAF, or …

Resorcylic acid lactones containing a cis-enone are susceptible to Michael addition
reactions and are potent inhibitors of several protein kinases. A structural-bioinformatics …