PET/fluorescence imaging: An overview of the chemical strategies to build dual imaging tools

J Ariztia, K Solmont, NP Moïse, S Specklin… - Bioconjugate …, 2022 - ACS Publications
Molecular imaging is a biomedical research discipline that has quickly emerged to afford the
observation, characterization, monitoring, and quantification of biomarkers and biological …

Immuno-PET of colorectal cancer with a CEA-targeted [68 Ga] Ga-nanobody: From bench to bedside

L Li, X Lin, L Wang, X Ma, Z Zeng, F Liu, B Jia… - European Journal of …, 2023 - Springer
Purpose An accurate diagnosis of colorectal carcinoma (CRC) can assist physicians in
developing reasonable therapeutic regimens, thereby significantly improving the patient's …

The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer

V Tolmachev, A Orlova, J Sörensen - Seminars in cancer biology, 2021 - Elsevier
Targeting of human epidermal growth factor type 2 (HER2) using monoclonal antibodies,
antibody-drug conjugates and tyrosine kinase inhibitors extends survival of patients with …

Protein scaffolds: antibody alternatives for cancer diagnosis and therapy

R Luo, H Liu, Z Cheng - RSC chemical biology, 2022 - pubs.rsc.org
Although antibodies are well developed and widely used in cancer therapy and diagnostic
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …

radionuclide molecular imaging targeting HER2 in breast cancer with a focus on molecular probes into clinical trials and small peptides

S Ge, J Li, Y Yu, Z Chen, Y Yang, L Zhu, S Sang… - Molecules, 2021 - mdpi.com
As the most frequently occurring cancer worldwide, breast cancer (BC) is the leading cause
of cancer-related death in women. The overexpression of HER2 (human epidermal growth …

Pilot study of a novel nanobody 68 Ga-NODAGA-SNA006 for instant PET imaging of CD8+ T cells

Y Wang, C Wang, M Huang, S Qin, J Zhao… - European Journal of …, 2022 - Springer
Purpose Positron emission tomography (PET) with specific diagnostic probes for quantifying
CD8+ T cells has emerged as a powerful technique for monitoring the immune response …

[HTML][HTML] The evolution of targeted radionuclide diagnosis of HER2-Positive breast cancer

OD Bragina, SM Deyev, VI Chernov, VM Tolmachev - Acta Naturae, 2022 - ncbi.nlm.nih.gov
This review examines the evolution of the radionuclide diagnosis of HER2-positive breast
cancer using various compounds as a targeting module in clinical practice: from full-length …

Radionuclide molecular imaging of EpCAM expression in triple-negative breast cancer using the scaffold protein DARPin Ec1

A Vorobyeva, E Bezverkhniaia, E Konovalova… - Molecules, 2020 - mdpi.com
Efficient treatment of disseminated triple-negative breast cancer (TNBC) remains an unmet
clinical need. The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the …

Influence of the position and composition of radiometals and radioiodine labels on imaging of Epcam expression in prostate cancer model using the DARPin Ec1

SM Deyev, T Xu, Y Liu, A Schulga, E Konovalova… - Cancers, 2021 - mdpi.com
Simple Summary Metastasis-targeting therapy might improve outcomes in oligometastatic
prostate cancer. Epithelial cell adhesion molecule (EpCAM) is overexpressed in 40–60% of …

Reducing the kidney uptake of high contrast CXCR4 PET imaging agents via linker modifications

D Kwon, Z Zhang, J Zeisler, HT Kuo, KS Lin, F Benard - Pharmaceutics, 2022 - mdpi.com
Purpose: The CXC chemokine receptor 4 (CXCR4) is highly expressed in many subtypes of
cancers, notably in several kidney-based malignancies. We synthesized, labeled, and …