MRI guided focused ultrasound-mediated delivery of therapeutic cells to the brain: a review of the state-of-the-art methodology and future applications
Stem cell and immune cell therapies are being investigated as a potential therapeutic
modality for CNS disorders, performing functions such as targeted drug or growth factor …
modality for CNS disorders, performing functions such as targeted drug or growth factor …
Reconsidering the route of drug delivery in refractory multiple sclerosis: Toward a more effective drug accumulation in the central nervous system
L Kalkowski, P Walczak, MP Mycko… - Medicinal Research …, 2023 - Wiley Online Library
Multiple sclerosis is a chronic demyelinating disease with different disease phenotypes. The
current FDA‐approved disease‐modifying therapeutics (DMTs) cannot cure the disease, but …
current FDA‐approved disease‐modifying therapeutics (DMTs) cannot cure the disease, but …
Validating a minipig model of reversible cerebral demyelination using human diagnostic modalities and electron microscopy
Background Inflammatory demyelinating diseases of the central nervous system, such as
multiple sclerosis, are significant sources of morbidity in young adults despite therapeutic …
multiple sclerosis, are significant sources of morbidity in young adults despite therapeutic …
Evaluation of myelin radiotracers in the lysolecithin rat model of focal demyelination: beware of pitfalls!
M Zhang, G Hugon, C Bouillot, R Bolbos… - Contrast media & …, 2019 - Wiley Online Library
The observation that amyloid radiotracers developed for Alzheimer's disease bind to
cerebral white matter paved the road to nuclear imaging of myelin in multiple sclerosis. The …
cerebral white matter paved the road to nuclear imaging of myelin in multiple sclerosis. The …
Local autoimmune encephalomyelitis model in a rat brain with precise control over lesion placement
Development of a novel, animal model for multiple sclerosis (MS) with reproducible and
predictable lesion placement would enhance the discovery of effective treatments …
predictable lesion placement would enhance the discovery of effective treatments …
Muscular contribution to adolescent idiopathic scoliosis from the perspective of stem cell-based regenerative medicine
E Brzoska, L Kalkowski, K Kowalski… - Stem Cells and …, 2019 - liebertpub.com
Adolescent idiopathic scoliosis (AIS) is a relatively frequent disease within a range 0.5%–
5.0% of population, with higher frequency in females. While a resultant spinal deformity is …
5.0% of population, with higher frequency in females. While a resultant spinal deformity is …
Finite element model to reproduce the effect of pre-stress and needle insertion velocity during infusions into brain phantom gel
Convection-enhanced delivery (CED) is a technique to bypass the blood-brain barrier and
deliver therapeutic agents into the brain. However, animal studies and preliminary clinical …
deliver therapeutic agents into the brain. However, animal studies and preliminary clinical …
Multimodally trackable and clinically translatable platform for modelling human demyelinating brain diseases by temporally dispersed chemically induced lesions in …
Background Despite advances in therapy, inflammatory demyelinating diseases of the
central nervous system, such as multiple sclerosis, remain important causes of morbidity …
central nervous system, such as multiple sclerosis, remain important causes of morbidity …
[引用][C] Research Article Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!
M Zhang, G Hugon, C Bouillot, R Bolbos, JB Langlois… - 2019