Mechanisms behind therapeutic potentials of mesenchymal stem cell mitochondria transfer/delivery

K Malekpour, A Hazrati, S Soudi… - Journal of Controlled …, 2023 - Elsevier
Mesenchymal stromal/stem cells (MSCs) perform their therapeutic effects through various
mechanisms, including their ability to differentiate, producing different growth factors …

Mitochondria transfer in brain injury and disease

LH Fairley, A Grimm, A Eckert - Cells, 2022 - mdpi.com
Intercellular mitochondria transfer is a novel form of cell signalling in which whole
mitochondria are transferred between cells in order to enhance cellular functions or aid in …

Emerging Treatment Strategies for Cerebral Ischemia–Reperfusion Injury

M Li, H Tang, Z Li, W Tang - Neuroscience, 2022 - Elsevier
Cerebral ischemia–reperfusion injury (CI/RI) injury is a common feature of ischemic stroke
which occurs when the blood supply is restored after a period of ischemia in the brain …

Mitochondrial transplantation attenuates cerebral ischemia‐reperfusion injury: possible involvement of mitochondrial component separation

Q Xie, J Zeng, Y Zheng, T Li, J Ren… - Oxidative Medicine …, 2021 - Wiley Online Library
Background. Mitochondrial dysfunctions play a pivotal role in cerebral ischemia‐reperfusion
(I/R) injury. Although mitochondrial transplantation has been recently explored for the …

Mitochondrial transplantation therapy for ischemia reperfusion injury: a systematic review of animal and human studies

K Hayashida, R Takegawa, M Shoaib, T Aoki… - Journal of Translational …, 2021 - Springer
Background Mitochondria are essential organelles that provide energy for cellular functions,
participate in cellular signaling and growth, and facilitate cell death. Based on their …

Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest

K Hayashida, R Takegawa, Y Endo, T Yin… - BMC medicine, 2023 - Springer
Abstract Background Mitochondrial transplantation (MTx) is an emerging but poorly
understood technology with the potential to mitigate severe ischemia–reperfusion injuries …

Oxidative stress, inflammation, and autophagy: potential targets of mesenchymal stem cells-based therapies in ischemic stroke

J He, J Liu, Y Huang, X Tang, H Xiao… - Frontiers in Neuroscience, 2021 - frontiersin.org
Ischemic stroke is a leading cause of death worldwide; currently available treatment
approaches for ischemic stroke are to restore blood flow, which reduce disability but are time …

Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges

S Hosseinian, PA Pour, A Kheradvar - Mitochondrion, 2022 - Elsevier
Mitochondria, known as the powerhouse of the cell, are at the center of healthy physiology
and provide cells with energy in the form of ATP. These unique organelles are also …

Stroke studies in large animals: Prospects of mitochondrial transplantation and enhancing efficiency using hydrogels and nanoparticle-assisted delivery

O Ulger, I Eş, CM Proctor, O Algin - Ageing Research Reviews, 2024 - Elsevier
One of the most frequent reasons of mortality and disability today is acute ischemic stroke,
which occurs by an abrupt disruption of cerebral circulation. The intricate damage …

Intranasal delivery of mitochondria attenuates brain injury by AMPK and SIRT1/PGC-1α pathways in a murine model of photothrombotic stroke

M Salman, AS Stayton, K Parveen, A Parveen… - Molecular …, 2024 - Springer
Ischemic stroke is one of the major causes of morbidity and mortality worldwide.
Mitochondria play a vital role in the pathological processes of cerebral ischemic injury, but …