The insular cortex, or “Island of Reil,” is hidden deep within the lateral sulcus of the brain.
Subdivisions within the insula have been identified on the basis of cytoarchitectonics, sulcal …

Background: Previous studies revealed that sleep deprivation (SD) impairs risk perception
and leads to poor decision-making efficiency. However, how risk perception is related to …

How human prefrontal and insular regions interact while maximizing rewards and
minimizing punishments is unknown. Capitalizing on human intracranial recordings, we …

Objective: In patients with epilepsy, the insula has been increasingly recognized as a
common site of seizures. There is growing interest in understanding the cognitive and …

Objective We explored the neural mechanisms underlying disadvantageous risk decision
making in un-medicated major depressive disorder patients who had recent suicide …

Positive valence system (PVS) deficits are increasingly recognized as important treatment
targets for depression and anxiety. Emerging behavioral treatments designed to upregulate …

Introduction Previous neuroimaging evidence highlighted the role of the insular and dorsal
anterior cingulate cortex (dACC) in conflict monitoring and decision-making, thus supporting …

Objective To investigate the application of graph theory with functional connectivity to
distinguish left from right temporal lobe epilepsy (TLE). Methods Alterations in functional …

A good‐based model, the central neurobiological model of economic decision‐making,
proposes that the orbitofrontal cortex (OFC) represents binary choice outcome, that is, the …

OBJECTIVE Operculoinsular cortectomy (also termed operculoinsulectomy) is increasingly
recognized as a therapeutic option for perisylvian refractory epilepsy. However, most …