Organ-on-a-chip: a new paradigm for drug development

C Ma, Y Peng, H Li, W Chen - Trends in pharmacological sciences, 2021 - cell.com
The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

Tumor-on-a-chip: from bioinspired design to biomedical application

X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

[HTML][HTML] Emergence of microfluidics for next generation biomedical devices

S Preetam, BK Nahak, S Patra, DC Toncu… - … and Bioelectronics: X, 2022 - Elsevier
The attention in lab-on-a-chip devices with their potent application in medical engineering
has prolonged swiftly over the last ten years. Travelling through the technology …

Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

Advances in engineering human tissue models

CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …

Organ‐on‐chip models: implications in drug discovery and clinical applications

R Mittal, FW Woo, CS Castro, MA Cohen… - Journal of cellular …, 2019 - Wiley Online Library
Before a lead compound goes through a clinical trial, preclinical studies utilize two‐
dimensional (2D) in vitro models and animal models to study the pharmacodynamics and …

[HTML][HTML] Bone/cartilage organoid on-chip: Construction strategy and application

Y Hu, H Zhang, S Wang, L Cao, F Zhou, Y Jing, J Su - Bioactive Materials, 2023 - Elsevier
The necessity of disease models for bone/cartilage related disorders is well-recognized, but
the barrier between ex-vivo cell culture, animal models and the real human body has been …

A review on methods for diagnosis of breast cancer cells and tissues

Z He, Z Chen, M Tan, S Elingarami, Y Liu, T Li… - Cell …, 2020 - Wiley Online Library
Breast cancer has seriously been threatening physical and mental health of women in the
world, and its morbidity and mortality also show clearly upward trend in China over time …

Recent advances in body-on-a-chip systems

JH Sung, YI Wang, N Narasimhan Sriram… - Analytical …, 2018 - ACS Publications
Microphysiological systems (MPS, also known as “organ-on-a-chip”,“body-on-a-chip”, or
“human-on-a-chip”) have emerged over the last 15 years as attractive systems to probe …

Recent innovations in cost-effective polymer and paper hybrid microfluidic devices

W Zhou, M Dou, SS Timilsina, F Xu, XJ Li - Lab on a Chip, 2021 - pubs.rsc.org
Hybrid microfluidic systems that are composed of multiple different types of substrates have
been recognized as a versatile and superior platform, which can draw benefits from different …