Since the discovery of conventional chemotherapy and the development of new target-
based agents, the importance of cytostasis in anticancer activity has been debated. This …

PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in
HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B …

In this paper we consider chemotherapy in a spatial model of tumor growth. The model,
which is of reaction-diffusion type, takes into account the complex interactions between the …

Cells grown in culture act as a model system for analyzing the effects of anticancer
compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell …

Understanding and improving the effects of combined drug treatments in metastatic
colorectal Cancer (mCRC) is a multidisciplinary and multiscale problem, that can benefit …

This review aims at presenting a synoptic, if not exhaustive, point of view on some of the
problems encountered by biologists and physicians who deal with natural cell proliferation …

Cell proliferation is controlled by many complex regulatory networks. Ourpurpose is to
analyse, through mathematical modeling, the effects of growth factors on the dynamics of the …

Background Discovery of key proliferative and/or survival cascades closely linked to the
biological effects of human epidermal growth factor receptor (HER) 1 (erbB-1) and/or HER2 …

Cancer is primarily a disease of the physiological control on cell population proliferation.
Tissue proliferation relies on the cell division cycle: one cell becomes two after a sequence …

Human gut flora-mediated non-digestible fraction of spent coffee grounds (hgf-NDSCG) was
evaluated for its chemopreventive effect and molecular mechanisms involved on human …