Cardiovascular complications, characterized by endothelial dysfunction and accelerated
atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes …

Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative
stress that contributes to the pathogenesis of this debilitating disease. This has prompted …

Mitochondria ensure the supply of cellular energy through the production of ATP via
oxidative phosphorylation. The alteration of this process, called mitochondrial dysfunction …

Whereas the pathogenesis of atherosclerosis has been intensively studied and described,
the underlying events that initiate cardiovascular disease are not yet fully understood. A …

Objective: We sought to understand the pathophysiological effects of depression by
examining group differences in serum levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a …

The rising prevalence of chronic metabolic disorders, such as obesity and type 2 diabetes,
most notably associated with cardiovascular diseases, has emerged as a major global …

The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide, and certain
population subgroups are especially vulnerable to the disease. To reduce T2DM risk and …

An increasing body of evidence suggests that oxidant stress is involved in the pathogenesis
of many cardiovascular diseases, including hypercholesterolemia, atherosclerosis …

Background—Our previous studies showed that transgenic mice that overexpress cardiac-
specific metallothionein (MT) are highly resistant to diabetes-induced cardiomyopathy. Zinc …

The metabolic syndrome is a clustering of obesity, diabetes, hyperlipidemia, and
hypertension that is occurring in increasing frequency across the global population …