Cellular and molecular pathobiology of heart failure with preserved ejection fraction

S Mishra, DA Kass - Nature Reviews Cardiology, 2021 - nature.com
Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure

R Kamel, J Leroy, G Vandecasteele… - Nature Reviews …, 2023 - nature.com
Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of
cardiac function by degrading cAMP and cGMP. In cardiomyocytes, multiple PDE isozymes …

Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial

R Pofi, E Giannetta, T Feola, N Galea… - Science Translational …, 2022 - science.org
Cyclic GMP–phosphodiesterase type 5 (PDE5) inhibition has been shown to counteract
maladaptive cardiac changes triggered by diabetes in some but not all studies. We …

Emerging evidence on membrane estrogen receptors as novel therapeutic targets for central nervous system pathologies

A Wnuk, K Przepiórska, BA Pietrzak… - International Journal of …, 2023 - mdpi.com
Nuclear-and membrane-initiated estrogen signaling cooperate to orchestrate the pleiotropic
effects of estrogens. Classical estrogen receptors (ERs) act transcriptionally and govern the …

Cyclic GMP and PKG signaling in heart failure

G Numata, E Takimoto - Frontiers in pharmacology, 2022 - frontiersin.org
Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates
protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by …

Sex differences in the time course and mechanisms of vascular and cardiac aging in mice: role of the smooth muscle cell mineralocorticoid receptor

JJ DuPont, SK Kim, RM Kenney… - American Journal of …, 2021 - journals.physiology.org
Aging is associated with heart and vascular dysfunction that contributes to cardiovascular
disease (CVD) risk. Clinical data support a sexual dimorphism in the time course of aging …

Sex differences and regulatory actions of estrogen in cardiovascular system

K Ueda, N Fukuma, Y Adachi, G Numata… - Frontiers in …, 2021 - frontiersin.org
Great progress has been made in the understanding of the pathophysiology of
cardiovascular diseases (CVDs), and this has improved the prevention and prognosis of …

Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice

S Mishra, N Sadagopan… - The Journal of …, 2021 - Am Soc Clin Investig
Central obesity with cardiometabolic syndrome (CMS) is a major global contributor to human
disease, and effective therapies are needed. Here, we show that cyclic GMP–selective …

Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload

KA Murphy, BA Harsch, CL Healy… - Cardiovascular …, 2022 - academic.oup.com
Aims Free fatty acid receptor 4 (Ffar4) is a G-protein-coupled receptor for endogenous
medium-/long-chain fatty acids that attenuates metabolic disease and inflammation …

On the search for the right definition of heart failure with preserved ejection fraction

A Kapłon-Cieślicka, K Kupczyńska… - Cardiology …, 2020 - journals.viamedica.pl
The definition of heart failure with preserved ejection fraction (HFpEF) has evolved from a
clinically based “diagnosis of exclusion” to definitions focused on objective evidence of …