Hierarchical nanomaterials assembled from peptoids and other sequence-defined synthetic polymers

Z Li, B Cai, W Yang, CL Chen - Chemical Reviews, 2021 - ACS Publications
In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures
plays an essential role in the construction of functional biomaterials. To develop synthetic …

Where biology and traditional polymers meet: The potential of associating sequence-defined polymers for materials science

AJ DeStefano, RA Segalman, EC Davidson - Jacs Au, 2021 - ACS Publications
Polymers with precisely defined monomeric sequences present an exquisite tool for
controlling material properties by harnessing both the robustness of synthetic polymers and …

A field guide to foldamers

DJ Hill, MJ Mio, RB Prince, TS Hughes… - Chemical …, 2001 - ACS Publications
The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Peptoid polymers: a highly designable bioinspired material

J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

In Situ Forming, Enzyme-Responsive Peptoid-Peptide Hydrogels: An Advanced Long-Acting Injectable Drug Delivery System

SM Coulter, S Pentlavalli, Y An, LK Vora… - Journal of the …, 2024 - ACS Publications
Long-acting drug delivery systems are promising platforms to improve patient adherence to
medication by delivering drugs over sustained periods and removing the need for patients to …

Peptoids and polypeptoids at the frontier of supra-and macromolecular engineering

N Gangloff, J Ulbricht, T Lorson, H Schlaad… - Chemical …, 2016 - ACS Publications
In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

NP Chongsiriwatana, JA Patch… - Proceedings of the …, 2008 - National Acad Sciences
Antimicrobial peptides (AMPs) and their mimics are emerging as promising antibiotic agents.
We present a library of “ampetoids”(antimicrobial peptoid oligomers) with helical structures …

Sequence programmable peptoid polymers for diverse materials applications

AS Knight, EY Zhou, MB Francis… - Advanced …, 2015 - Wiley Online Library
Polymer sequence programmability is required for the diverse structures and complex
properties that are achieved by native biological polymers, but efforts towards controlling the …

Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure

K Kirshenbaum, AE Barron… - Proceedings of the …, 1998 - National Acad Sciences
We have synthesized and characterized a family of structured oligo-N-substituted-glycines
(peptoids) up to 36 residues in length by using an efficient solid-phase protocol to …

Structure–function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function

SA Fowler, HE Blackwell - Organic & biomolecular chemistry, 2009 - pubs.rsc.org
Oligomers of N-substituted glycine, or peptoids, are versatile tools to probe biological
processes and hold promise as therapeutic agents. An underlying theme in the majority of …