A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

Hippo signaling is an evolutionarily conserved network that has a central role in regulating
cell proliferation and cell fate to control organ growth and regeneration. It promotes …

Background: Smooth muscle cells (SMCs) play significant roles in atherosclerosis via
phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and …

The focal nature of atherosclerotic lesions suggests an important role of local hemodynamic
environment. Recent studies have demonstrated significant roles of Yes-associated protein …

Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …

Rationale: Microvascular inflammation and endothelial dysfunction secondary to unchecked
activation of endothelium play a critical role in the pathophysiology of sepsis and organ …

Rapid regeneration of smooth muscle after vascular injury is essential for maintaining
arterial function. The existence and putative roles of resident vascular stem cells (VSCs) in …

The heart is the first organ formed during mammalian development. A properly sized and
functional heart is vital throughout the entire lifespan. Loss of cardiomyocytes because of …

The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration
of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely …