Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

The pursuit to discover the fundamental biology and mechanisms of aging within the context
of the physical and social environment is critical to designing interventions to prevent and …

An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

We use a genome-wide association of 1 million parental lifespans of genotyped subjects
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …