Growth of new blood vessels is considered requisite to cancer progression. Recent findings
revealed that in addition to inducing angiogenesis, tumor-derived factors alter endothelial …

Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis
or transform to initiate cancer. Despite their importance, there are no described quality …

Zebrafish have become a powerful model of mammalian lipoprotein metabolism and lipid
cell biology. Most key proteins involved in lipid metabolism, including cholesteryl ester …

Endothelial cells (EC) differentiate from multiple sources, including the cardiopharyngeal
mesoderm, which gives rise also to cardiac and branchiomeric muscles. The enhancers …

Transcription factors (TFs) constitute an essential component of epigenetic regulation. They
contribute to the progression of vascular diseases by regulating epigenetic gene expression …

Hematopoietic stem cells are regulated by endothelial and mesenchymal stromal cells in the
marrow niche1-3. Leukemogenesis was long believed to be solely driven by genetic …

Hematopoietic stem cell transplantation requires a collection of hematopoietic cells from
patients or stem cell donors. Granulocyte colony-stimulating factor (G-CSF) is widely used in …

Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models
of human tissue development but display can be difficult to rationally engineer, display …

2020-10-07 Assigned to THE CHILDREN'S MEDICAL CENTER CORPORATION
reassignment THE CHILDREN'S MEDICAL CENTER CORPORATION ASSIGNMENT OF …

Hematopoietic stem cells (HSCs) possess the ability to sustain the continuous production of
all blood cell types throughout an organism's lifespan. While primarily located in the bone …